Averous, J., et al., Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
All these drugs are present a demonstrated senolytic acitivity in vitro and in vivo (Fig.1) but their efficiency in human still need to be investigated
The observation that PARP inhibition partly rescues vitamin C-treated cells may suggest that the toxic effect of DHA uptake is not caused by ROS alone, since restoring NAD + levels and glycolysis with the PARP inhibitor may actually decrease PPP flux and NADPH production, and aggravate the redox stress
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