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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

Vascul Pharmacol, 2018

(5) GPX1 rs1800668*A

Determining the site of action for peptides can be challenging, as it is often unclear whether the effect is mediated within the brain or by peripheral tissues