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The effect of metformin on islet incretin receptor expression As metformin upregulates the expression of incretin receptors in an islet cell line in vitro [26], we assessed whether metformin modulates pancreatic or islet incretin receptor expression in murine islets

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For example, a plasmid expression vector carrying a dominant-negative mutant of the MCP-1 gene has been shown to significantly reduce the incidence of severe pancreatitis and improve the 48-h survival rate following disease onset