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First, healthy-user bias is a major concern: individuals prescribed newer, more expensive agents such as semaglutide may systematically differ from comparator groups in terms of health behaviors, dietary patterns, physical activity, adherence to medical care, and access to healthcare resources

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When the documentation is vague, the conservative research approach is to use the shorter 28-day window, avoid large reconstituted batches, and reconstitute only what the current phase of the protocol actually needs