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Recommendations for Those on T4-Only Medications T4-only medication (such as Synthroid, Levoxyl, Tirosint, Eltroxin, and generic levothyroxine) has a five- to nine-day half-life, which means that once you have become stable on the current dosage, it can take up to nine days for 50 percent of the dose to clear the body

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Chronic stress, poor sleep, and unresolved emotional or physical trauma can also trigger or worsen fatigue

Statistical comparisons among different groups were performed by using one-way analysis of variance (ANOVA) followed by posthoc multiple comparisons (LSD test)