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This is followed by the release of nesfatin-1 which stimulates cholecystokinin secretion leading to a rise in bile salts from gallbladder emptying, and the binding of Takeda P protein coupled receptor 5 (TGR5) onto the surface of the enteroendocrine cells, all of which eventually culminates in GLP-1 secretion [9]

We also see these obesity-related diseases now starting in our adolescents, so there certainly is harm to ignoring it and not offering them treatment, Ashley Shoemaker, MD, MSCI, associate professor of pediatrics and pediatric endocrinology at Monroe Carell Jr

10.1126/sciadv.aba8968 38 WangY.WuX.RenZ.LiY.ZouW.ChenJ.et al (2023)