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The amounts of total reduced and oxidized glutathione were quantified using a modified Tietze method by Adams ( Safety Measurements Any adverse event during the course of the study was monitored and reported to the study staff at week 6 (visit 5) or week 12 (visit 8) in the clinic or directly to the principal investigator throughout the study

Blood samples were collected at specific time points, and the results indicated that P-Mn/TI@mHSA exhibited a half-life of around 20 h (Supplementary Fig