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More recently, the probiotic Lactobacillus plantarum SG5 has been shown to ameliorate motor deficits, neuronal death and the decreased colonic GLP-1 created by MPPT, indicating that the neuroprotective effect of SG5 likely involves modulation of the gut microbiota and, significantly, the GLP-1/PCG 1 pathway [49]

143 By modulating calcium responses to glutamate and membrane depolarization, 144 and AMPA receptors, 139,145 GLP-1 RA may play important roles in regulating neuronal plasticity

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This can cause physical and emotional symptoms that may disrupt sleep, lower energy, or affect emotional health