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Brain tissues were placed in PBS for 24 hours before being embedded in paraffin wax and sectioned onto histology slides

It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

While human clinical data is limited, years of anecdotal use and animal studies have helped shape reliable dosing practices

Normally, the oesophagus has hard wearing lining of squamous cells