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This implies that DPP4is, characterized by their small molecular size (below 500 Da), can effectively hinder the enzyme's catalytic site, inhibiting its function, while preserving the molecule's capacity to act as a costimulatory factor without disruption

Sitagliptin: A review of its use in the management of type 2 diabetes mellitus

The comparator arm was placebo, a GLP-1 RA (subcutaneous administration of semaglutide 1 mg once-weekly) and basal insulin in three [18, 19, 22], one [24, 25] and two trials [20, 21], respectively, while one trial included both a placebo arm and a GLP-1 RA arm (dulaglutide 1.5 mg once-weekly) [23]