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(2004) were the first to synthesize polymeric nanocarriers, PEG-poly (amino acid) micelles that accumulated in solid tumor tissues and were subsequently used in clinical studies [407]

In order to further increase the production of GSH, the addition of amino acid precursors (5 mM glutamic acid, 5 mM cysteine and 5 mM glycine) was single shot after 36-h cultivation for feeding assay