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The structural similarity of GLP-1 and glucagon as well as of their respective receptors, along with the inherent low-potency promiscuity of these hormones at the other respective receptors (apart from the pancreas, where glucagon has recently been demonstrated to also act on GLP-1R [173]), suggested the possibility of integrating both activities into a sequence-intermixed single molecule hybrid

Engineered solely for preclinical investigations, each batch of CJC-1295 without DAC undergoes a comprehensive quality assessment and includes complete documentation, including a Certificate of Analysis (COA), purity data, and structural verification

[DOI] [PMC free article] [PubMed] [Google Scholar] Sirohi S., Schurdak J.D., Seeley R.J., Benoit S.C., Davis J.F

It also regulates sebum production and improves overall skin tone and texture