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Compared to the active state, ECL1 moves toward helix I by 5 when measured at the N-terminal tip of the helix (C of Q211), and ECL1 residue W214 is reoriented ~180 o from an outside-facing position to a position pointing towards helix I

Xenobiotica 48, 10371049

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The market for weight loss drugs is huge: There are roughly 750 million obese people worldwide, including about 42 percent of adults in the United States, where obesity-related illnesses incur billions of dollars in health care costs each year