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50mg vial with 2.5ml bacteriostatic water: 50mg 2.5ml = 20mg/ml For 1mg dose: 1mg 20mg/ml = 0.05ml = 5 units on U-100 syringe 50mg vial with 2ml bacteriostatic water: 50mg 2ml = 25mg/ml For 1mg dose: 1mg 25mg/ml = 0.04ml = 4 units on U-100 syringe 100mg vial with 5ml bacteriostatic water: 100mg 5ml = 20mg/ml For 2mg dose: 2mg 20mg/ml = 0.1ml = 10 units on U-100 syringe Higher concentrations mean smaller injection volumes but require more precise syringe handling
N-acetylcysteine (NAC) is a modified form of the amino acid L-cysteine that has been used in clinical medicine for several decades
Cancer cells were rendered more susceptible to proapoptotic agents such as celecoxib, etoposide, and TRAIL when WA activated the ETS-like transcription factor 1/C-EBP identical protein pathway and the extracellular signal-regulated kinase (ERK) ribosomal S6 kinase signalling pathway, leading to the expression of death receptor 5
Most compounds specifically targeting cancer NADPH metabolism are in preclinical studies, thus there are still challenges to address before these compounds enter the clinic
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