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Main outcome parameters and results: The main efficacy parameter was the effect of treatment on 6- and 12-month changes from baseline in nerve conduction velocity (NCV) and amplitude in the sensory (ulnar, sural and median) and motor (median, ulnar and peroneal) nerves

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This modification was designed to induce more pronounced disturbances in glucose and lipid metabolism, thereby facilitating the establishment of a stable and reproducible metabolic disorder model