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APAP administration increases ROS in the drosophila fat body and depletes systemic glutathione In the mammalian liver, APAP is bio-converted into the toxic metabolite NAPQI by the Cytochrome P450 enzyme CYP2E1 4

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Lang E, Zelenak C, Eberhard M, Bissinger R, Rotte A, Ghashghaeinia M, et al