Membrane-bound DPP4 is widely expressed on the cell surface of various tissues, including intestine, liver, pancreas, kidney, spleen, lung and bone marrow, while sDPP4 is widely distributed in serum and body fluids such as saliva, cerebrospinal fluid, seminal fluid and bile (Mulvihill and Drucker, 2014
This process can lead to oxidative stress, which affects homeostasis, membrane fragility, signal transduction, and cell survival
Key management strategies include: Regular monitoring: Blood glucose levels, HbA1c (a measure of average blood sugar over 23 months), blood pressure, heart rate, and lipid profiles should be checked regularly as advised by your healthcare team
In addition, a large-scale clinical study demonstrated that GLP-1 analogues could reduce the mortality of patients with prostate cancer and diabetes (19)