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WARNING Before using topiramate, tell your health care provider about your medical history, especially if you have: narrow angle glaucoma and nearsightedness kidney problems, such as kidney stones liver problems depression or thoughts of suicide lung or breathing problems metabolic acidosis high blood ammonia levels long-term diarrhea low body temperature a diet high in fat and low in carbohydrates, aka a ketogenic diet brittle bones Topiramate may cause some people to sweat less

For a comprehensive overview of all supplements that pair well with GLP-1 medications, including those that help with other side effects like hair loss , headaches , and fatigue , see our comprehensive supplements guide

Results are expected in 2026

When people say they feel "tired" on semaglutide, they could be experiencing different types of fatigue: Physical weakness or low energy (most common): Feeling like everyday tasks require more effort Mental fatigue : Brain fog or difficulty concentrating Sleepiness : Actually feeling drowsy during the day Semaglutide-related fatigue is typically experienced as physical weakness or low energy rather than excessive sleepiness