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We used the small bowel preparation grade system described by Esaki et al [5] in this study

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4: prolonged and frequent withdrawal (30 s) accompanied by shaking, licking and/or vocalization ( 2.5.2 Hot plate test In this experiment, we assessed thermal hyperalgesia related to neuropathic pain in rats by measuring their paw withdrawal latency (PWL) using a hot plate apparatus (Harvard Apparatus, Holliston, MA)

The Grammy winner revealed that her biggest inspiration for losing weight was to alleviate the intense back pain she would feel after performing on stage