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Recent studies indicate that metformin strengthens the protective function of the intestinal mucosal barrier by increasing the abundance of Akkermansia muciniphila and the number of goblet cells, resulting in a thicker mucus layer that reduces inflammation in the intestines ( Lactobacillus spp

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For example, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote fibroblast activation, collagen synthesis, and vascularization [3], while antimicrobial peptides (AMPs) contribute to infection control and immune modulation at wound sites [21, 22]

Safety and tolerability also remain key considerations