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These data imply that the absence of Gclc prevents B cells from establishing GC reactions, and therefore, hinders antibody production

To address this, we isolated primary mouse hepatocytes and infected them with adenoviruses expressing Chac1 or GFP, followed by treatment with BSA or BSA-conjugated fatty acids to mimic chow and HFD conditions, respectively

doi: 10.1016/j.biopha.2017.03.026

Hsieh WY, Hsieh MH (2015) The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms