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a pharmaceutical composition comprising a compound of any one of the preceding clauses in combination with one or more carriers, diluents, or excipients, or a combination thereof

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It is typically included in the form of L-citrulline or citrulline malate

Observational studies and multinational cohorts have also reported lower risks of HF hospitalization, major cardiovascular events, and all-cause mortality with combined therapy compared with either class alone [28,29,30]