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As a public health proposition, this new class of weight-loss drugs is a positive development, but for those who may think that an injection, and now a pill, is a silver bullet that eliminates the need for lifestyle modifications like diet and exercise, think again

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You should not take semaglutide or tirzepatide if you have: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN2) History of pancreatitis or gallbladder disease Severe kidney or liver disease Diabetic retinopathy (in some cases) Severe gastrointestinal disease Pregnancy or breastfeeding This is not a complete list of contraindications

But consistent use over weeks will make the biggest difference to overall muscle function and recovery time