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In a follow-up proof-of-concept study by Aviles-Olmos et al., the longevity of motor and non-motor effects were assessed up to 24 months after the trial

[7] [12] However, Phase 2 trials are not powered to detect rare cardiovascular outcomes, and longer-term Phase 3 data including dedicated cardiovascular outcome trials will be essential to fully characterise the cardiac safety profile of retatrutide