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However, in total only 126 genes (out of nearly 13,000 detected genes) were differentially regulated in semaglutide-compared to vehicle-treated LPD mice (47 upregulated, 79 downregulated), revealing mild remodeling of the liver transcriptome upon semaglutide treatment (Figure 4B)

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Clinical trials show most patients who experienced diarrhea continued treatment successfully once the symptom resolved