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however, those with alcohol usage disorders randomized to receive exenatide once weekly over 26 weeks showed no reduction in heavy drinking

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Key Points The prevalence of obesity is increasing worldwide as a result of high-calorie diets and sedentary lifestyles Current anti-obesogenic therapies have limited effectiveness and/or severe adverse effects Substances in plants and mushrooms have anti-obesogenic and antidiabetic effects by regulating appetite, nutrient digestion and absorption, adipogenesis, energy expenditure, insulin sensitivity and composition and function of the gut microbiota Clinical data relating to the effectiveness of plants and mushrooms are limited, but preliminary evidence suggests they can have beneficial effects on body weight and fat accumulation in humans Herbal and fungal phytonutrients could be combined with existing weight-loss treatments to optimize anti-obesogenic effects Abstract Obesity is reaching global epidemic proportions as a result of factors such as high-calorie diets and lack of physical exercise