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Finally, the strain MG12345 was constructed by deleting glgB (Table 1)

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Instead the Fab 3F52/ECD structure is compatible with a tilted conformation of the ECD, where Fab 3F52 occupies partially the orthosteric binding site of the GLP-1R TM domain explaining the competitive effect of Fab 3F52 on BMS21-induced activation of GLP-1R (Fig

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