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BV and melittin influence several intracellular pathways, and their blockage triggers apoptosis., melittin inhibits the PI3K/Akt/mTOR pathway in breast cancer cells (Pandey et al., 2023b), or liver cancer cells (Lv et al., 2023)

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Recently, studies have identified loss of trimethylation at lysine 27 of histone H3 (H3K27me3) in a subset of malignant peripheral nerve sheath tumors reflecting inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED