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In biological systems, reactive oxygen species (ROS), such as superoxide (O 2 ) and hydrogen peroxide (H 2 O 2 ), play important signaling roles but may also contribute to cellular damage and disease development

Unknown long-term effects : There is no long-term safety data for either compound used individually in the general population, let alone in combination

Biochemistry 47 (28), 75577566

supplements of selenium of 200 g/d (as selenium yeast or selenomethionine), generally considered to be safe, have been associated with toxic effects (alopecia, dermatitis, squamous cell carcinoma, type-2 diabetes mellitus, high-grade prostate cancer) in North Americans ( Reference Lippman, Klein and Goodman 106 Reference Stranges, Marshall and Natarajan 108 )