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2a, the cumulative incidence of composite outcomes was consistently higher in the GLP-1RA group compared to the DPP-4i group, demonstrating a statistically significant increased risk in the former, with a log-rank p value of less than 0.001

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From a strategic perspective, METRNL illustrates the limitations of purely receptor-centric approaches to peptide drug discovery

This reveals whether your body responds strongly to semaglutide's appetite effects or whether combining medication with dietary changes will yield better results for your unique genetics