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This study, which appears to be unique to the literature in that it systematically assessed time-of-day effects on antioxidant efficacy, is suggestive of a time-of-day-dependent antioxidant response relevant to sleep and sleepiness (Figure 9B)

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The anticonvulsant drugs phenobarbital, phenytoin (Dilantin), and carbamazepine (Tegretol) may also lower plasma vitamin E concentrations in individuals with epilepsy (129)