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No increased risk of pancreatitis, diabetic retinopathy complications, or major cardiovascular events was observed, though longer-term safety data continues to accumulate

Cardiovascular and Kidney Outcomes No dedicated prospective RCT has yet been powered to compare combined SGLT2i and GLP-1RA therapy versus monotherapy for cardiovascular and kidney endpoints, although the ongoing PRECIDENTD trial is expected to address this gap [36]

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Without Insurance: Average retail price: $1,396 per 30-day supply before any manufacturer discounts or pharmacy coupons With BCBS Insurance: Your costs depend on where your plan places Ozempic in its drug tier system: Tier 2 (Preferred Brand): $30-$75 copay per month Tier 3 (Non-Preferred Brand): $66-$125 copay per month (most common) Tier 5-6 (Specialty Tiers): $150-$300+ copay or 25-33% coinsurance When Ozempic is covered by insurance, out-of-pocket costs vary widely depending on plan design, copay tiers, and deductibles, with some members paying low copays and others paying higher ones