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The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in -cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205)

Its also crucial to seek immediate medical attention if you experience severe abdominal pain, blood in your stool, or persistent vomiting, as these could indicate a more serious condition that affects your quality of life.