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Ultimately, by inhibiting abnormal proliferation of PASMCs and endothelial cells, reducing extracellular matrix deposition, and improving myocardial energy metabolism patterns, it achieves the therapeutic goal of delaying pulmonary vascular remodeling and the progression of right heart failure, providing a unique multi-dimensional regulatory strategy of natural drugs for PH treatment

Unlike prior reviews that focus on individual herbs or broadly defined adaptogens, the present review integrates mechanistic, preclinical, and clinical evidence across these three agents to highlight their complementary rather than redundant actions

Bacteriostatic water contains 0.9% benzyl alcohol as a preservative