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609 PARP inhibitor Actovegin: Actovegin ameliorated sensory nerve conduction velocity (SNCV) and IENFD of experimental DN via mechanisms involving suppression of PARP activation

Retention times for 350 authentic standards were checked manually to aid metabolite identification

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Studies suggest that it may achieve this by downregulating pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) while upregulating anti-inflammatory mediators like interleukin-10 (IL-10)