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Iron is also stored as a pigment called hemosiderin, which is an ill-defined deposit of protein and iron, created by macrophages where excess iron is present, either locally or systemically, e.g., among people with iron overload due to frequent blood cell destruction and the necessary transfusions their condition calls for

Moreover, enhanced presence of vascular smooth muscle cells was noted in plaques treated with P-Mn/TI@mHSA, as demonstrated by -smooth muscle actin (-SMA) antibody staining (Fig