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One saw tirzepatide knock off an average of 17.8% body weight compared to 12.4% from semaglutide after 72 weeks.3 But GLP-1 receptor agonism likely isnt superior in tirzepatide, as it appears to have an imbalanced effect favoring its agonism of glucose-dependent insulinotropic polypeptide (GIP) receptors

We can thank the Kardashians