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Within the same synthetic pathways for GSH production, adequate levels of several B vitamins are essential, as they serve as enzymatic cofactors in multiple metabolic pathways contributing to GSH synthesis: (i) vitamin B6 contributes to normal cysteine synthesis, regarded as the rate-limiting factor in GSH synthesis

This strategy also enables the development of pan-KRAS degraders against a broader spectrum of KRAS mutations

NAD+ NAD+, as a research coenzyme boosting metabolism, may induce mild side effects in experimental models, primarily during initial administration