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By week four of uninterrupted use, melanocyte MC1R density can drop by 3040%, requiring progressively higher doses to achieve the same tanning response

This represents a marked contrast with strains such as Faecalibacterium prausnitzii, which depend on the fermentation of dietary fiber to produce short-chain fatty acids, or Oxalobacter formigenes, which specializes in oxalate metabolism [16]