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The heavy GCLC is both the catalytic unit and the regulatory site of GSH feedback inhibition, while the light subunit regulates the activity of the holo-enzyme by modulating the affinity of the two regulatory sites of GCLC, that for glutamate and that for glutathione thereby making the enzyme more efficient and less sensitive to feedback inhibition

The efficacy of the specific enzyme blend used in AllerGzyme is supported by robust clinical data

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The druglike and orally bioavailable compounds identified herein are active in animal models of schistosomiasis with a broader range of developmental stages targeted than the drug of choice, PZQ