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Genetics, sun exposure, lifestyle and overall oxidative burden influence outcomes

Primary keratinocyte culture is limited by their variability in culture conditions, and their susceptibility to irritants varies with the number of passages

Additionally, certain cellular events including autophagy, endoplasmic reticulum stress, inflammatory infiltration and microcirculatory dysfunction, have been found involvement with the pathogenesis of APAP-caused liver injury (Yan et al., 2018)