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78 Most of these drugs interact with the monoamine neurotransmitter transporters (dopamine transporter [DAT], SERT, NET), in the CNS to varying degrees altering levels of dopamine, serotonin, and noradrenaline, and therefore, in overdose can produce a range of overlapping toxidromes (serotonergic, sympathomimetic, and so on) depending on their particular receptor specificities