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doi: 10.1016/j.archoralbio.2010.11.021 446 WenW.CaoH.HuangY.TuJ.WanC.WanJ.et al

Many healthcare systems find that strategic coverage policies, coupled with patient assistance programs and outcomes-based contracts with manufacturers, help balance immediate pharmaceutical costs against reduced hospitalizations, complications, and overall care utilization

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The condition is multifactorial, involving systemic inflammation, altered growth factor signaling, and reduced hormone levels, particularly androgens, estrogens and progestins