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Although not considered a change in structure to the BBB per se, endothelial cells can increase leukocyte adhesion molecule expression leading to increased leukocyte extravasation into the brain parenchyma under pathological conditions [58, 59]

Rodents have higher metabolic rates relative to body mass, different adipose tissue distribution, and a brown fat compartment that is more metabolically active

Apart from imparting smoother, firmer and clearer skin, Alpha lipoic acid is believed to exert numerous soothing effects to the skin and the body

Numerous studies have revealed their potential benefits for various autoimmune diseases, including arthritis [20], and bronchial asthma [21], and ulcerative colitis [22] among others [23, 24]