Signs that microdosing may not be your best approach If you have been at a dose for four or more weeks with zero noticeable changes in appetite, energy, or food behavior, and you have experienced no GI side effects whatsoever, you may be someone whose receptor sensitivity requires higher doses to engage
Furthermore, the low consumption of vegetables and fruits causes a lack of exogenous antioxidants, while an excessive intake of animal proteins (mainly red and processed meat) and fats has been associated with increased oxidants, increasing the risk of immune-mediated disorders, including autoimmune thyroid diseases [186, 187]
Furthermore, exendin-4 substantially decreased hepatic fatty acid uptake and synthesis and ameliorated alcohol-induced changes in liver/body weight ratio compared to untreated animals [95]
Ozempic is designed for long-term use, and its benefits are most obvious with consistent, ongoing treatment