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In addition to the extent of hormone deficiency or excess, changes in appetite regulation, energy expenditure, body weight and body composition might contribute to the adverse effect on glucose homeostasis
Leading up to the Metsera acquisition, Pfizer management was pretty open about its interest in doing a deal to re-enter this space with differentiated long-acting and oral GLP-1 candidates
The cyclic lactam bridge provides structural stability across a broad pH range , avoid strongly alkaline conditions above pH 9 that can promote lactam hydrolysis over extended incubation, and avoid oxidising conditions that could modify the Trp9 residue
However, their high price tags $12,648 per year for tirzepatide and $13,618 per year for semaglutide exceed the typical cost-effectiveness threshold of $100,000 to $150,000 per quality-adjusted life-year (QALY)
