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The SURMOUNT-5 head-to-head comparison trial provided definitive evidence of tirzepatide's superiority over semaglutide, with Zepbound producing 20.2% average weight loss compared to 13.7% for Wegovy, a 47% greater relative reduction

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However, this isnt generally seen It is likely that GLPs normalise or stabilise the system rather than simply blunt it. She said: The research is still early, and this is an area that genuinely warrants more clinical investigation

Decreased appetite and weight loss: As Ozempic slows gastric emptying, a person may feel satiated quickly (early satiety) or even lose their appetite entirely