semaglutide recombinant synthesis Synthetic Routes Semaglutide and Follow-On Peptide Therapeutics:

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In an aspect, expression vector that is used in the process of the present invention can be commercially available expression vectors or custom designed vectors selected from pET vectors, pd451sR and the like

The fermentation medium further comprises acids selected from citric acid, boric acid and the like or combination thereof

The process as claimed in claim 1, wherein various amino acids of (3-31) amino acid fragment of Semaglutide are optionally protected with different protecting groups which include alkyloxy carbonyl such as methoxy carbonyl, ethoxy carbonyl, tert.butoxy carbonyl (Boc)