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Significant transient increases in serum tryptase level (20% over baseline plus 2 ng/mL) or other MC-derived mediators, such as urinary histamine/ N -methyl histamine, leukotriene E 4 , or prostaglandin D 2 /2,3-dinor-11prostaglandin F 2 alpha (PGF2) metabolite over baseline during a period of increased symptoms

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Combined NNMT inhibition and lean-diet substitution improves adiposity and body-composition endpoints in DIO mice