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doi: 10.1016/j.cej.2019.122079 83 ChenQFengLLiuJZhuWDongZWuYet al
With overdose it can produce muscarinic & nicotinic symptoms SLUDE Muscarinic : nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis Nicotinic side effects are comprised chiefly of muscle cramps, fasiculation and weakness Overdosage may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death Pharmacokinetics for MG: Pyridostigmine is available in 3 dosage forms for MG: 1) oral solution
10.1172/jci.insight.85717 JCI Insight
396 AChEIs boost postsynaptic stimulation by increasing both the level and the action duration of ACh, thereby enhancing cognitive and behavioral functions in patients
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